Qamishli is culturally diverse—with Arabs, Kurds, Assyrians, and Armenians—and historically known for coexistence and agricultural trade. As a regional administrative and commercial center, it plays a key role in northeastern Syria. Conflict has strained services like water and electricity, but the local community continues social and economic life amid challenges.

As of 2026, Qamishli is relatively calmer but still struggles with basic services challenges like water shortages and intermittent electricity, affecting daily life and health. Many residents were displaced, with some returning slowly. The city still needs significant infrastructure rehabilitation and economic support.